41 articles - From Friday Sep 16 2022 to Friday Sep 23 2022
Guidelines, position statements, white papers, technical reviews, consensus statements, etc…
meta-analyses and systematic reviews
| Rheumatology (Oxford) |
Individual participant data meta-analysis of metabolomics on sustained knee pain in primary osteoarthritis patients. Though further investigations are needed, our results provide potential predictive biomarkers and drug targets that could serve as a marker for poor response and be modified pre-operatively to improve knee pain and surgical response to TKA. |
Withdrawal of MTX in rheumatoid arthritis patients on bDMARD/tsDMARD plus methotrexate at target: a systematic review and meta-analysis. However, MTX withdrawal did not decrease remission rates assessed by DAS28, SDAI, CDAI or ACR/EULAR Boolean remission (RR 0.90 [0.81, 1.01], 0.93 [0.77, 1.11], 0.90 [0.74, 1.11], 0.95 [0.70, 1.29], respectively). Withdrawing MTX slightly increases the RA disease activity in patients treated at target with bDMARDs/tsDMARDs plus MTX and has limited effects for patients with deep remission. |
RCT, clinical trials, retrospective studies, etc…
| Ann Rheum Dis |
Olokizumab, a monoclonal antibody against interleukin-6, in combination with methotrexate in patients with rheumatoid arthritis inadequately controlled by tumour necrosis factor inhibitor therapy: efficacy and safety results of a randomised controlled phase III study. Direct inhibition of IL-6 with OKZ resulted in significant improvements in the signs and symptoms of rheumatoid arthritis compared with PBO in TNF-IR patients with a similar safety profile as observed for monoclonal antibodies to the IL-6 receptor. |
Safety and immunogenicity of a third COVID-19 vaccination in patients with immune-mediated inflammatory diseases compared with healthy controls. Our clinical trial data support the immunogenicity and safety of a third COVID-19 vaccination in patients with IMIDs. However, effects of DMARD therapy on immunogenicity should be considered. |
Type II collagen facilitates gouty arthritis by regulating MSU crystallisation and inflammatory cell recruitment. Our study demonstrates that the release of CII and protein-crystal adsorption modifies the crystal profile and promotes the early immune response in MSU-mediated inflammation. These findings open up a new path for understanding the relationship between cartilage injuries and the early immune response in gout flares. |
Understanding sex-related differences in healthcare utilisation among patients with inflammatory arthritis: a population-based study. Female patients with IA have higher healthcare utilisation than male patients which may indicate biological differences in disease course or sociocultural differences in healthcare-seeking behaviour. |
| Arthritis Care Res (Hoboken) |
Addressing Competency in Rheumatology Telehealth Care Delivery. The Rheumatology TCs represent the first adaptation of the AAMC TCs to subspecialty care, expanding the scope to include rheumatology fellowship graduates and additional domains of rheumatology practice. These competencies can guide curricular innovations and measurements of proficiency in telehealth care delivery among rheumatology trainees and experienced clinicians, enhancing the care provided to patients with rheumatic diseases. |
Cost effectiveness of telehealth-delivered exercise and dietary weight loss programs for knee osteoarthritis within a 12-month randomised trial. Telehealth-delivered programs targeting exercise with dietary intervention for people with knee OA who have overweight/obesity are likely to be cost-effective, particularly if potential long-term gains from weight loss and work productivity are realised. |
Performance of Modified ALMS and BLISS Criteria with Standard of Care Treatment in Two US Healthcare Systems. In a primarily Black, uninsured LN population, despite achieving similar CR rates at 12 months, the incidence of ESRD and mortality exceeded those observed in controlled clinical trials with placebo arms. |
| Arthritis Res Ther |
Association between radiographic hand osteoarthritis and bone microarchitecture in a population-based sample. This hypothesis generating data suggests that bone size and trabecular disorganization increase with both osteophyte formation and JSN (proximal more than distal), while local vBMD decreases. This process appears to be primarily at the site of pathology rather than nearby unaffected bone. |
| Arthritis Rheumatol |
Association of Modified Systemic Lupus Erythematosus Responder Index Attainment and Long-Term Clinical Outcomes: A Five-Year Prospective Study. Furthermore, mSRI responder status at one year predicted clinical benefit at subsequent years across most outcomes, including damage (OR 0.58-0.69, p<0.05). In SLE patients with active disease receiving standard of care, mSRI attainment predicts favourable outcomes over long-term follow up, supporting the clinical meaningfulness of SRI as an SLE trial endpoint. |
De novo gain-of-function variations in LYN lead to an early onset systemic autoinflammatory disorder. This study, which demonstrates the pathogenicity of the first three LYN variations identified in SAID patients, delineates the phenotypic spectrum of a disease entity characterized by an early onset severe inflammatory disease affecting neonates with no family history of SAID. All three variations affect the same tyrosine residue located in the C-terminus of Lyn, thereby underlining the critical role of this residue in the proper regulation of Lyn activity in humans. |
Dynamic prediction of pulmonary hypertension in systemic sclerosis using landmark analysis. The Kco based model had the greatest discriminating ability (Harrell's C 0.903). Our findings strongly support the importance of PFT trends over time in identifying patients at risk of PH. |
HECTD1-mediated ubiquitination and degradation of Rubicon regulates autophagy and osteoarthritis pathogenesis. More importantly, HECTD1-mediated Rubicon degradation regulates chondrocyte autophagy, which mitigates stress-induced chondrocyte death and subsequent OA progression. HECTD1 plays a crucial role in OA pathogenesis in which HECTD1 regulates chondrocyte autophagy by ubiquitinating and targeting Rubicon for proteasomal degradation. |
Human mesenchymal stem cells and derived extracellular vesicles reduce sensory neuron hyperexcitability and pain behaviors in murine osteoarthritis. Furthermore, we found that NGF-induced sensory neuron hyperexcitability is prevented by MSC-EV treatment (p < |
Proteomic landscape mapping of organ-resolved Behçet's syndrome using in-depth plasma proteomics for identifying HABP2 expression associated with vascular involvement. HABP2, TNC, and SERPINA3 were validated as potential biomarkers for the clinical assessment of vascular BS and treatment targets. Our results provide valuable insight into the pathogenesis of organ-resolved BS in terms of proteomic characteristics and potential biomarkers for vascular BS clinical assessment and treatment in the future. |
Reliability and diagnostic accuracy of radiography for the diagnosis of calcium pyrophosphate deposition: performance of the novel definitions developed by an international multidisciplinary working group. Radiography demonstrated to be specific for CPPD (92%), but sensitivity remained low in al sites and in the overall diagnosis (54%). The new imaging definitions of CPPD are highly specific against the gold standard of histological diagnosis; when described findings are present these definitions allow for a definite diagnosis of CPPD, rather than other calcium-containing crystal depositions; instead a negative finding does not exclude the diagnosis. |
| Rheumatology (Oxford) |
An ankylosing spondylitis risk variant alters osteoclast differentiation. These results reveal a novel understanding of the bone formation and reabsorbing imbalance in AS. The new bone formation phenotype can be attributed to the inhibition of osteoclast differentiation by a more functional PSMB1 gene. |
Continuing specialist care into adulthood in young people with juvenile idiopathic arthritis: a retrospective cohort study using electronic health records in England. Two-thirds of young people with JIA continue to receive specialist care beyond age 18. This is useful information for children and young people with JIA and their families planning for their future, and for clinicians planning healthcare services. |
Eosinophilic fasciitis (Shulman syndrome) - recognition of the histological spectrum allows for new insights into possible pathomechanisms. Our findings highlight a specific immune phenotype of leucocyte infiltrates in EF along features of perifascicular pathology similar to DM, while there is no evidence of hypoxia-mediated or type I Interferon associated processes with perifascicular fibre atrophy, indicating different pathomechanisms of muscle involvement. |
Extent of fibrosis and lung function decline in patients with systemic sclerosis and interstitial lung disease: data from the SENSCIS trial. Data from the SENSCIS trial suggest that patients with SSc-ILD are at risk of ILD progression and benefit from nintedanib largely irrespective of their extent of fibrotic ILD at baseline. |
Longitudinal study of patients with antimelanoma differentiation-associated gene 5 antibody-positive dermatomyositis associated interstitial lung disease. MDA5+ DM-ILD patients had a high mortality rate despite aggressive treatment. Patients who survived the first year usually showed a significant improvement in serological markers and pulmonary function during the long-term follow-up. |
Obstetric Outcomes in Women with Rheumatic Disease and COVID-19 in the Context of Vaccination Status. Additionally, the need for COVID-19 pharmacological treatment was uncommon in pregnant women with RMD regardless of vaccination status. These results support active promotion of COVID-19 vaccination in women with RMD who are pregnant or planning a pregnancy. |
Profiling of Serum Oxylipins Identifies Distinct Spectrums and Potential Biomarkers in Young People with Very Early Onset Gout. Young men with very early onset gout have distinct oxylipin spectrums, especially those derived from AA (arachidonic acid), EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid). Differential oxylipins could serve as candidate serum biomarkers in differentiating gout from hyperuricemia. |
Successful stopping of biologic therapy for remission in children and young people with juvenile idiopathic arthritis. This analysis identified factors associated with successful cessation of biologics for remission in JIA as absence of uveitis, prior treatment with tocilizumab and starting biologics earlier in the disease course. Further research is needed to guide clinical recommendations. |
Whole grain consumption and risk of radiographic knee osteoarthritis: a prospective study from the Osteoarthritis Initiative. Our findings revealed a significant inverse association of whole-grain consumption with knee OA risk. These findings provide evidence that eating a diet rich in whole grains may be a potential nutritional strategy to prevent knee OA. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Arthritis Care Res (Hoboken) |
Socioeconomic Status and Medication Use in Rheumatoid Arthritis: A Scoping Review. There is some evidence that SES affects use of medications in patients with RA, however multiple definitions of SES have been utilised, making comparisons between studies difficult. Prospective studies with consistently defined SES will be needed to determine whether differences in medication use accounts for the poorer outcomes experienced by lower SES patients. |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Ann Rheum Dis |
| Arthritis Rheumatol |
| Rheumatology (Oxford) |
Letters to the editors and authors’ replies